Preliminary Program
Friday, June 26
15h00 – 18h00 Registration
19h00 Introductory Remarks
Rémi Quirion, McGill University, Canada
François Marceau, Laval University, Kinin 2009
Réjean Couture, President, Canadian Branch, INPS
Abba Kastin, President, INPS
Opening lectures
19h15 Jean-Pierre Changeux (Collège de France, Paris, France)
From allostery to consciousness: toward a molecular biology
of higher brain functions
19h45 Gold Medal Recipient, Frey-Werle Foundation of the Henning L. Voigt Family
20h15 Welcoming Reception and light Dinner
Saturday, June 27
Session I
From a peptide to a drug : Rational drug design
Chairs: Fernando Albericio & Alain Fournier
8h30 – 8h55 Alain Couvineau (Paris)
Structure-function relationship of the VPAC1 receptor:
a prototypical of class B GPCR
8h55 – 9h20 Les Miranda (Thousand Oaks, CA)
Design and synthesis of conformationally constrained glucagon-like
peptide-1 derivatives with increased plasma stability and prolonged
in vivo activity
9h20 – 9h45 Catherine Llorens-Cortes (Paris)
Apelin receptors in body fluid homeostasis
and cardiovascular functions
9h45 – 10h10 Fernando Albericio (Barcelona)
Kahalalide F: From the sea to clinical trials
10h10 – 10h45 Break
10h45 – 11h10 Jocelyn Dupuis (Montréal)
Development of radiolabeled adrenomedullin analogs designed
for molecular imaging of the pulmonary circulation
11h10 – 11h35 to be selected from abstracts
11h35 – 12h00 Waleed Dahno (Hoffman-LaRoche, Nutley, NJ)
(to be confirmed)
12h00 – 14h00 Complimentary Lunch
Session II
Peptide receptors: In vivo molecular pharmacology
Chairs: Emiliana Borrelli & Martin Beaulieu
14h00 – 14h25 Michael Bader (Berlin)
Kinin receptors as drug targets:
Evidence from genetically altered animal models
14h25 – 14h50 Martin Beaulieu (Québec)
Arrestin mediatiated signaling in vivo: from behavior
to protein complex
14h50 – 15h15 Laura Bohn (Columbus, OH)
Functional selectivity of receptor signaling hinges on beta-arrestin2
15h15 – 15h45 Emiliana Borrelli (Irvine, CA)
Receptor KOs, behavior
15h40 – 16h15 Break
16h15 – 16h40 Raul Gainetdinov (Durham, NC)
Role of GRKs and Arrestins in cocaine actions (or) Physiological
functions mediated by TAAR1
16h40 – 17h05 Silvio Gutkind (Bethesda, MD)
RTKs in vivo
17h05 – 17h30 to be selected from abstracts
Sunday, June 28
Session III
Hypertension, diabetes and obesity
Chairs: Jean-Pierre Girolami & Réjean Couture
8h30 – 8h55 Daniel Bichet (Montreal)
Nephrogenic Diabetes Insipidus; a transgenic mouse model generated
from patients with regulatory AVPR2 mutations
8h55 – 9h20 Oscar Carretero (Detroit, MI)
Ac-SDKP, a tetrapeptide: Role in target organ damage in hypertension
and diabetes
9h20 – 9h45 Carsten Tschöpe (Berlin)
Kinin receptors and cardiac inflammation under diabetic conditions
9h45 – 10h10 Helmy M. Siragy (Charlottesville, VA)
Angiotensin AT2 receptors: Is it time for new therapy?
10h10 – 10h45 Break
10h45 – 11h10 Vincenzo Di Marzo (Naples, Italy)
Cannabinoids in diabetes
11h10 – 11h35 Edward P. Feener (Boston, MA)
Kallikrein-kinin system in diabetic retinopathy
11h35 – 12h00 to be selected from abstracts
12h00 – 14h00 Complimentary Lunch
Session IV
Poster Session I (odd numbers)
Chair: Pedro d’Orléans-Juste
14h00 – 16h00 Poster Discussion
16h15 – 17h00 Samuel Weiss (Calgary)
Plenary Lecture - NeuroStem cells: from discovery
to clinical applications
17h00 Cocktail
Monday, June 29
Session V
Inflammation, immunology and blood chemistry
Chairs: Michael Bader & François Marceau
8h30 – 8h55 Keith R. McCrae (Cleveland, OH)
Biology of the kininogen deficient mouse
8h55 – 9h20 Stephen M. Taylor (Brisbane, Australia)
Immunopathology and C5a receptors: Do all roads lead to Rome?
9h20 – 9h45 Joao Batista Calixto (Florianopolis, Brazil)
New advances about the role of B1 and B2 receptors for kinins in
persistent pain and inflammatory processes
9h45 – 10h10 Amrita Ahluwalia (London, UK)
Endothelial Kinin B1 receptors and inflammatory cell recruitment
10h10 – 10h45 Break
10h45 – 11h10 Mami Noda (Fukuoka, Japan)
Bradykinin as an attractant of immune cells in the brain
and its possible neuroprotective role
11h10 – 11h35 Nancy Brown (Nashville, TN)
Bradykinin: The good, the bad, and the ugly
11h35 – 12h00 to be selected from abstracts
12h00 – 14h00 Complimentary Lunch
Session VI
Poster Session II (even numbers)
Chair: Pedro d’Orléans-Juste
14h00 – 16h00 Poster Discussion
19h00 Award Ceremony
Prizes of the Frey-Werle Foundation of the Henning L. Voigt Family
Poster Awards
21h00 Symposium Dinner, L’Astral
Tuesday, June 30
Session VII
Pain
Chairs: Philippe Walker & Yves De Koninck
8h30 – 8h55 Rohini Kuner (Heidelberg, Germany)
Unravelling the functional role of Gq/11-coupled GPCRs in nociceptors
8h55 – 9h20 Marc Landry (Bordeaux)
Neuropeptide modulation of synaptic transmission through
Gal1/GAGAB receptor interaction
9h20 – 9h45 Philippe Saret (Sherbrooke)
Neurotensin receptors: new therapeutic targets for the treatment
of chronic pain
9h45 – 10h10 To be announced
10h10 – 10h45 Break
10h45 – 11h10 Rémi Quirion (Montréal)
On the role of CGRP and adrenomedullin in pain and tolerance
to opiates
11h10 – 11h35 Yves De Koninck (Québec)
A novel approach to detect interactions in intact tissue;
role of NK-1 receptor oligomerization
11h35 – 12h00 to be selected from abstracts
12h00 – 14h00 Complimentary Lunch
Session VIII
Neuropeptides in CNS disorders
1st Meeting of the Canadian Branch of the International Neuropeptide Society
Chairs: Henri Doods & Rémi Quirion
14h00 – 14h25 Abba Kastin (Baton Rouge, LA)
Neuropeptides and the blood-brain barrier
14h25 – 14h50 To be confirmed
14h50 – 15h15 Henri Doods (Biberach, Germany)
CGRP antagonists for the treatment of migraine and pain
15h15 – 15h45 David Vaudry (Rouen, France)
Neuroprotective action of VIP-PACAP related peptides
15h40 – 16h15 Break
16h15 – 16h40 Ted George (Bethesda, MD)
Neurokinin 1 receptor antagonism as a possible therapy
for alcoholism
16h40 – 17h05 Masashi Yanagisawa (Dallas, TX)
Orexins as key regulators of stress and sleep
17h05 – 17h30 to be selected from abstracts
17h30 – 18h00 Concluding Remarks
Domenico Regoli (Ferrara, Italy)